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Crystallisation inhibitor

Crystallisation inhibitor
Crystallisation of drug reduces the bioavailability of the drug resulting in reduction of efficacy of formulation. Crystallisation inhibitors prevent the crystallisation of the drug by increasing viscosity or by formation of hydrogen bonds with the drug.

Examples: Povidone grades, Copovidone grades
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Crystallisation inhibitor
Crystallisation inhibitor
Primary function
Crystallisation inhibitor
Typical use level
In creams and lotions, levels can be as low as 3% w/w.
Benefits / Claims
Prevent further growth of suspended particles in case of creams/lotions containing dispersed drug.
Suitable for
Cream/ Emulsion
Softgel Capsules
Oral Solutions

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