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pH modifier

pH modifier
The pH of a product can affect the stability of the drug, efficacy of preservatives as well as the viscosity of the formulation. pH modifiers are an important component of aqueous based topical dosage forms. pH modifiers include acidifying, alkalizing and buffering agents.

Acid
  • Organic: Citric acid monohydrate/anhydrous, Lactic acid

  • Inorganic: Phosphoric acid, Sulfuric acid, Hydrochloric acid


Base
  • Organic: Tromethamine, Trolamine

  • Inorganic: Sodium hydroxide, Potassium hydroxide
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pH modifier
pH modifier
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pH Modifier
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Usage levels are fixed based on the pH required. It can be as low as 0.05% and as high as 7%
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Help maintain the pH of the dosage form in an acceptable range, thus contributing towards maintaining the physicochemical stability of the dosage form
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